Seviteronel, a Novel CYP17 Lyase Inhibitor and Androgen Receptor Antagonist, Radiosensitizes AR-Positive Triple Negative Breast Cancer Cells

Increased rates of locoregional recurrence (LR) have been observed in triple negative breast cancer (TNBC) despite multimodality therapy, including radiation (RT). Recent data suggest inhibiting the androgen receptor (AR) may be an effective radiosensitizing strategy, and AR is expressed in 15–35% o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Endocrinol (Lausanne)
Prif Awduron: Michmerhuizen, Anna R., Chandler, Benjamin, Olsen, Eric, Wilder-Romans, Kari, Moubadder, Leah, Liu, Meilan, Pesch, Andrea M., Zhang, Amanda, Ritter, Cassandra, Ward, S. Tanner, Santola, Alyssa, Nyati, Shyam, Rae, James M., Hayes, Daniel, Feng, Felix Y., Spratt, Daniel, Wahl, Daniel, Eisner, Joel, Pierce, Lori J., Speers, Corey
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2020
Pynciau:
Endocrinology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027396/
https://ncbi.nlm.nih.gov/pubmed/32117061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2020.00035
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