Seviteronel, a Novel CYP17 Lyase Inhibitor and Androgen Receptor Antagonist, Radiosensitizes AR-Positive Triple Negative Breast Cancer Cells

Increased rates of locoregional recurrence (LR) have been observed in triple negative breast cancer (TNBC) despite multimodality therapy, including radiation (RT). Recent data suggest inhibiting the androgen receptor (AR) may be an effective radiosensitizing strategy, and AR is expressed in 15–35% o...

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Detalhes bibliográficos
Publicado no:Front Endocrinol (Lausanne)
Main Authors: Michmerhuizen, Anna R., Chandler, Benjamin, Olsen, Eric, Wilder-Romans, Kari, Moubadder, Leah, Liu, Meilan, Pesch, Andrea M., Zhang, Amanda, Ritter, Cassandra, Ward, S. Tanner, Santola, Alyssa, Nyati, Shyam, Rae, James M., Hayes, Daniel, Feng, Felix Y., Spratt, Daniel, Wahl, Daniel, Eisner, Joel, Pierce, Lori J., Speers, Corey
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027396/
https://ncbi.nlm.nih.gov/pubmed/32117061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2020.00035
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