DDRE-19. PHASE 0/I TRIAL OF MYCOPHENOLATE MOFETIL COMBINED WITH RADIATION TO OVERCOME GLIOBLASTOMA TREATMENT RESISTANCE BY TARGETING DE-NOVO PURINE METABOLISM

BACKGROUND: Radiation resistance is one of the major limitations for effective control of glioblastoma. Guanosine triphosphate (GTP) supplementation promotes glioblastoma radioresistance. Conversely, GTP depletion overcomes glioblastoma radioresistance by slowing the repair of radiation-induced DNA...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neurooncol Adv
Prif Awduron: Umemura, Yoshie, Sun, Yilun, Junck, Larry, Leung, Denise, Kim, Michelle, Al-Holou, Wajd, Sagher, Oren, Heth, Jason, Lyssiotis, Costas, Marini, Bernard, Lawrence, Theodore, Wahl, Daniel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2021
Pynciau:
Supplement Abstracts
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992240/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdab024.041
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