DDRE-19. PHASE 0/I TRIAL OF MYCOPHENOLATE MOFETIL COMBINED WITH RADIATION TO OVERCOME GLIOBLASTOMA TREATMENT RESISTANCE BY TARGETING DE-NOVO PURINE METABOLISM

BACKGROUND: Radiation resistance is one of the major limitations for effective control of glioblastoma. Guanosine triphosphate (GTP) supplementation promotes glioblastoma radioresistance. Conversely, GTP depletion overcomes glioblastoma radioresistance by slowing the repair of radiation-induced DNA...

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Dades bibliogràfiques
Publicat a:Neurooncol Adv
Autors principals: Umemura, Yoshie, Sun, Yilun, Junck, Larry, Leung, Denise, Kim, Michelle, Al-Holou, Wajd, Sagher, Oren, Heth, Jason, Lyssiotis, Costas, Marini, Bernard, Lawrence, Theodore, Wahl, Daniel
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2021
Matèries:
Supplement Abstracts
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992240/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdab024.041
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