DDRE-19. PHASE 0/I TRIAL OF MYCOPHENOLATE MOFETIL COMBINED WITH RADIATION TO OVERCOME GLIOBLASTOMA TREATMENT RESISTANCE BY TARGETING DE-NOVO PURINE METABOLISM

BACKGROUND: Radiation resistance is one of the major limitations for effective control of glioblastoma. Guanosine triphosphate (GTP) supplementation promotes glioblastoma radioresistance. Conversely, GTP depletion overcomes glioblastoma radioresistance by slowing the repair of radiation-induced DNA...

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Détails bibliographiques
Publié dans:Neurooncol Adv
Auteurs principaux: Umemura, Yoshie, Sun, Yilun, Junck, Larry, Leung, Denise, Kim, Michelle, Al-Holou, Wajd, Sagher, Oren, Heth, Jason, Lyssiotis, Costas, Marini, Bernard, Lawrence, Theodore, Wahl, Daniel
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2021
Sujets:
Supplement Abstracts
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992240/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdab024.041
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