Confluence of Theory and Experiment Reveal the Catalytic Mechanism of the Varkud Satellite Ribozyme

The Varkud Satellite (VS) ribozyme catalyzes site-specific RNA cleavage and ligation, and serves as an important model system to understand RNA catalysis. Here we combine stereospecific phosphorothioate substitution, precision nucleobase mutation and linear free energy relationship measurements with...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Chem
Prif Awduron: Ganguly, Abir, Weissman, Benjamin P., Giese, Timothy J., Li, Nan-Sheng, Hoshika, Shuichi, Rao, Saieesh, Benner, Steven A., Piccirilli, Joseph A., York, Darrin M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7389185/
https://ncbi.nlm.nih.gov/pubmed/31959957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-019-0391-x
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