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Evidence for a Catalytic Strategy to Promote Nucleophile Activation in Metal-Dependent RNA-Cleaving Ribozymes and 8-17 DNAzyme
[Image: see text] An unique catalytic strategy was recently reported for the glmS ribozyme [ Bingaman et al., Nat. Chem. Biol.2017, 13, 439−44528192411] that involves promotion of productive hydrogen bonding of the O2′ nucleophile to facilitate its activation. We provide broad evidence of this strat...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | ACS Catal |
|---|---|
| Prif Awduron: | , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Chemical Society
2019
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| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6902279/ https://ncbi.nlm.nih.gov/pubmed/31840007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.9b02035 |
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