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Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme

Existing evidence suggests that the Varkud satellite (VS) ribozyme accelerates the cleavage of a specific phosphodiester bond using general acid-base catalysis. The key functionalities are the nucleobases of adenine 756 in helix VI of the ribozyme, and guanine 638 in the substrate stem loop. This re...

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Main Authors: Wilson, Timothy J., Li, Nan-Sheng, Lu, Jun, Frederiksen, John K., Piccirilli, Joseph A., Lilley, David M. J.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900685/
https://ncbi.nlm.nih.gov/pubmed/20547881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004255107
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