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Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme
Existing evidence suggests that the Varkud satellite (VS) ribozyme accelerates the cleavage of a specific phosphodiester bond using general acid-base catalysis. The key functionalities are the nucleobases of adenine 756 in helix VI of the ribozyme, and guanine 638 in the substrate stem loop. This re...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2900685/ https://ncbi.nlm.nih.gov/pubmed/20547881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004255107 |
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