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General acid-base catalysis mediated by nucleobases in the hairpin ribozyme
The catalytic mechanism by which the hairpin ribozyme accelerates cleavage or ligation of the phosphodiester backbone of RNA has been incompletely understood. There is experimental evidence for an important role for an adenine (A38) and a guanine (G8), and it has been proposed that these act in gene...
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| Główni autorzy: | , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3707309/ https://ncbi.nlm.nih.gov/pubmed/22958171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3067429 |
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