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General acid-base catalysis mediated by nucleobases in the hairpin ribozyme

The catalytic mechanism by which the hairpin ribozyme accelerates cleavage or ligation of the phosphodiester backbone of RNA has been incompletely understood. There is experimental evidence for an important role for an adenine (A38) and a guanine (G8), and it has been proposed that these act in gene...

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Detalhes bibliográficos
Main Authors: Kath-Schorr, Stephanie, Wilson, Timothy J., Li, Nan-Sheng, Lu, Jun, Piccirilli, Joseph A., Lilley, David M. J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707309/
https://ncbi.nlm.nih.gov/pubmed/22958171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3067429
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