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A guanine nucleobase important for catalysis by the VS ribozyme

A guanine (G638) within the substrate loop of the VS ribozyme plays a critical role in the cleavage reaction. Replacement by any other nucleotide results in severe impairment of cleavage, yet folding of the substrate is not perturbed, and the variant substrates bind the ribozyme with similar affinit...

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Detalhes bibliográficos
Main Authors: Wilson, Timothy J, McLeod, Aileen C, Lilley, David M J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868910/
https://ncbi.nlm.nih.gov/pubmed/17464286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601698
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