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A guanine nucleobase important for catalysis by the VS ribozyme
A guanine (G638) within the substrate loop of the VS ribozyme plays a critical role in the cleavage reaction. Replacement by any other nucleotide results in severe impairment of cleavage, yet folding of the substrate is not perturbed, and the variant substrates bind the ribozyme with similar affinit...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1868910/ https://ncbi.nlm.nih.gov/pubmed/17464286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601698 |
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