Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme

Existing evidence suggests that the Varkud satellite (VS) ribozyme accelerates the cleavage of a specific phosphodiester bond using general acid-base catalysis. The key functionalities are the nucleobases of adenine 756 in helix VI of the ribozyme, and guanine 638 in the substrate stem loop. This re...

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Detaylı Bibliyografya
Asıl Yazarlar: Wilson, Timothy J., Li, Nan-Sheng, Lu, Jun, Frederiksen, John K., Piccirilli, Joseph A., Lilley, David M. J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2010
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900685/
https://ncbi.nlm.nih.gov/pubmed/20547881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004255107
Etiketler: Etiketle
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