Deciphering site 3 interactions of interleukin 12 and interleukin 23 with their cognate murine and human receptors

Interleukin (IL)–12 and IL-23 belong to the IL-12 type family and are composite cytokines, consisting of the common β subunit p40 and the specific cytokine α subunit p35 and p19, respectively. IL-12 signals via the IL-12Rβ1·IL-12Rβ2 receptor complex, and IL-23 uses also IL-12Rβ1 but engages IL-23R a...

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Publicado en:J Biol Chem
Autores principales: Esch, Alessandra, Masiarz, Anna, Mossner, Sofie, Moll, Jens M., Grötzinger, Joachim, Schröder, Jutta, Scheller, Jürgen, Floss, Doreen M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383385/
https://ncbi.nlm.nih.gov/pubmed/32518162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013935
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