Identification of Canonical Tyrosine-dependent and Non-canonical Tyrosine-independent STAT3 Activation Sites in the Intracellular Domain of the Interleukin 23 Receptor

Signaling of interleukin 23 (IL-23) via the IL-23 receptor (IL-23R) and the shared IL-12 receptor β1 (IL-12Rβ1) controls innate and adaptive immune responses and is involved in the differentiation and expansion of IL-17-producing CD4(+) T helper (T(H)17) cells. Activation of signal transducer and ac...

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Autores principales: Floss, Doreen M., Mrotzek, Simone, Klöcker, Tobias, Schröder, Jutta, Grötzinger, Joachim, Rose-John, Stefan, Scheller, Jürgen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707643/
https://ncbi.nlm.nih.gov/pubmed/23673666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.432153
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