Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases

The interleukin (IL)-12–type cytokines IL-12 and IL-23 are involved in T-helper (Th) 1 and Th17 immunity, respectively. They share the IL-12 receptor β1 (IL-12Rβ1) as one component of their receptor signaling complexes, with IL-12Rβ2 as second receptor for IL-12 and IL-23R for IL-23 signal transduct...

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Publicado en:Mol Biol Cell
Main Authors: Floss, Doreen M., Klöcker, Tobias, Schröder, Jutta, Lamertz, Larissa, Mrotzek, Simone, Strobl, Birgit, Hermanns, Heike, Scheller, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2016
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945146/
https://ncbi.nlm.nih.gov/pubmed/27193299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-12-1645
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