Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130

Cytokine signaling is transmitted by cell-surface receptors that function as biological switches controlling mainly immune-related processes. Recently, we have designed synthetic cytokine receptors (SyCyRs) consisting of GFP and mCherry nanobodies fused to transmembrane and intracellular domains of...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mossner, Sofie, Kuchner, Marcus, Fazel Modares, Nastaran, Knebel, Birgit, Al-Hasani, Hadi, Floss, Doreen M., Scheller, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458808/
https://ncbi.nlm.nih.gov/pubmed/32611765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013927
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