Suramin and NF449 are IP5K inhibitors that disrupt inositol hexakisphosphate–mediated regulation of cullin–RING ligase and sensitize cancer cells to MLN4924/pevonedistat

Inositol hexakisphosphate (IP(6)) is an abundant metabolite synthesized from inositol 1,3,4,5,6-pentakisphosphate (IP(5)) by the single IP(5) 2-kinase (IP5K). Genetic and biochemical studies have shown that IP(6) usually functions as a structural cofactor in protein(s) mediating mRNA export, DNA rep...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Zhang, Xiaozhe, Shi, Shaodong, Su, Yang, Yang, Xiaoli, He, Sining, Yang, Xiuyan, Wu, Jing, Zhang, Jian, Rao, Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383383/
https://ncbi.nlm.nih.gov/pubmed/32493769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014375
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