Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function

The family of cullin-RING E3 Ligases (CRLs) and the constitutive photomorphogenesis 9 (COP9) signalosome (CSN) form dynamic complexes that mediate ubiquitylation of 20% of the proteome, yet regulation of their assembly/disassembly remains poorly understood. Inositol polyphosphates are highly conserv...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Scherer, Paul C., Ding, Yan, Liu, Zhiqing, Xu, Jing, Mao, Haibin, Barrow, James C., Wei, Ning, Zheng, Ning, Snyder, Solomon H., Rao, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822622/
https://ncbi.nlm.nih.gov/pubmed/26976604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525580113
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