Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome

The Cullin-RING ligases (CRLs) are the largest family of ubiquitin E3s activated by neddylation and regulated by the deneddylase COP9 signalosome (CSN). The inositol polyphosphate metabolites promote the formation of CRL–CSN complexes, but with unclear mechanism of action. Here, we provide structura...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Lin, Hong, Zhang, Xiaozhe, Liu, Li, Fu, Qiuyu, Zang, Chuanlong, Ding, Yan, Su, Yang, Xu, Zhixue, He, Sining, Yang, Xiaoli, Wei, Xiayun, Mao, Haibin, Cui, Yasong, Wei, Yi, Zhou, Chuanzheng, Du, Lilin, Huang, Niu, Zheng, Ning, Wang, Tao, Rao, Feng
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2020
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049131/
https://ncbi.nlm.nih.gov/pubmed/32047038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911998117
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