Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome

The Cullin-RING ligases (CRLs) are the largest family of ubiquitin E3s activated by neddylation and regulated by the deneddylase COP9 signalosome (CSN). The inositol polyphosphate metabolites promote the formation of CRL–CSN complexes, but with unclear mechanism of action. Here, we provide structura...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lin, Hong, Zhang, Xiaozhe, Liu, Li, Fu, Qiuyu, Zang, Chuanlong, Ding, Yan, Su, Yang, Xu, Zhixue, He, Sining, Yang, Xiaoli, Wei, Xiayun, Mao, Haibin, Cui, Yasong, Wei, Yi, Zhou, Chuanzheng, Du, Lilin, Huang, Niu, Zheng, Ning, Wang, Tao, Rao, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049131/
https://ncbi.nlm.nih.gov/pubmed/32047038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911998117
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