Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathways through specific substrate receptors. The COP9 signalosome (CSN) deactivates CRLs by removing NEDD8 from activated Cullins. Here we present structures of the neddylated and deneddylated CSN-CRL2 complexes by combining single-par...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Faull, Sarah V., Lau, Andy M. C., Martens, Chloe, Ahdash, Zainab, Hansen, Kjetil, Yebenes, Hugo, Schmidt, Carla, Beuron, Fabienne, Cronin, Nora B., Morris, Edward P., Politis, Argyris
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6707232/
https://ncbi.nlm.nih.gov/pubmed/31444342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11772-y
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