Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4–signalosome complex to regulate DNA repair and cell death

Inositol polyphosphates containing an energetic pyrophosphate bond are formed primarily by a family of three inositol hexakisphosphate (IP6) kinases (IP6K1–3). The Cullin-RING ubiquitin ligases (CRLs) regulate diverse biological processes through substrate ubiquitylation. CRL4, comprising the scaffo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rao, Feng, Xu, Jing, Khan, A. Basit, Gadalla, Moataz M., Cha, Jiyoung Y., Xu, Risheng, Tyagi, Richa, Dang, Yongjun, Chakraborty, Anutosh, Snyder, Solomon H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234592/
https://ncbi.nlm.nih.gov/pubmed/25349427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417900111
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