An alternate conformation of HCV E2 neutralizing face as an additional vaccine target

To achieve global elimination of hepatitis C virus (HCV), an effective cross-genotype vaccine is needed. The HCV envelope glycoprotein E2 is the main target for neutralizing antibodies (nAbs), which aid in HCV clearance and protection. E2 is structurally flexible and functions in engaging host recep...

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Pubblicato in:Sci Adv
Autori principali: Tzarum, Netanel, Giang, Erick, Kadam, Rameshwar U., Chen, Fang, Nagy, Kenna, Augestad, Elias H., Velázquez-Moctezuma, Rodrigo, Keck, Zhen-Yong, Hua, Yuanzi, Stanfield, Robyn L., Dreux, Marlene, Prentoe, Jannick, Foung, Steven K. H., Bukh, Jens, Wilson, Ian A., Law, Mansun
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2020
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380959/
https://ncbi.nlm.nih.gov/pubmed/32754640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb5642
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