An alternate conformation of HCV E2 neutralizing face as an additional vaccine target

To achieve global elimination of hepatitis C virus (HCV), an effective cross-genotype vaccine is needed. The HCV envelope glycoprotein E2 is the main target for neutralizing antibodies (nAbs), which aid in HCV clearance and protection. E2 is structurally flexible and functions in engaging host recep...

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Udgivet i:Sci Adv
Main Authors: Tzarum, Netanel, Giang, Erick, Kadam, Rameshwar U., Chen, Fang, Nagy, Kenna, Augestad, Elias H., Velázquez-Moctezuma, Rodrigo, Keck, Zhen-Yong, Hua, Yuanzi, Stanfield, Robyn L., Dreux, Marlene, Prentoe, Jannick, Foung, Steven K. H., Bukh, Jens, Wilson, Ian A., Law, Mansun
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380959/
https://ncbi.nlm.nih.gov/pubmed/32754640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb5642
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