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A mechanistic view of enzyme evolution
New enzyme functions often evolve through the recruitment and optimization of latent promiscuous activities. How do mutations alter the molecular architecture of enzymes to enhance their activities? Can we infer general mechanisms that are common to most enzymes, or does each enzyme require a unique...
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| Pubblicato in: | Protein Sci |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley & Sons, Inc.
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7380680/ https://ncbi.nlm.nih.gov/pubmed/32557882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3901 |
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