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How mutational epistasis impairs predictability in protein evolution and design

There has been much debate about the extent to which mutational epistasis, that is, the dependence of the outcome of a mutation on the genetic background, constrains evolutionary trajectories. The degree of unpredictability introduced by epistasis, due to the non‐additivity of functional effects, st...

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Dades bibliogràfiques
Publicat a:Protein Sci
Autors principals: Miton, Charlotte M., Tokuriki, Nobuhiko
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918425/
https://ncbi.nlm.nih.gov/pubmed/26757214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2876
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