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How mutational epistasis impairs predictability in protein evolution and design
There has been much debate about the extent to which mutational epistasis, that is, the dependence of the outcome of a mutation on the genetic background, constrains evolutionary trajectories. The degree of unpredictability introduced by epistasis, due to the non‐additivity of functional effects, st...
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| Publicado en: | Protein Sci |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4918425/ https://ncbi.nlm.nih.gov/pubmed/26757214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2876 |
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