FACS-array–based cell purification yields a specific transcriptome of striatal medium spiny neurons in a murine Huntington disease model

Huntington disease (HD) is a neurodegenerative disorder caused by expanded CAG repeats in the Huntingtin gene. Results from previous studies have suggested that transcriptional dysregulation is one of the key mechanisms underlying striatal medium spiny neuron (MSN) degeneration in HD. However, some...

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Vydáno v:J Biol Chem
Hlavní autoři: Miyazaki, Haruko, Yamanaka, Tomoyuki, Oyama, Fumitaka, Kino, Yoshihiro, Kurosawa, Masaru, Yamada-Kurosawa, Mizuki, Yamano, Risa, Shimogori, Tomomi, Hattori, Nobutaka, Nukina, Nobuyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380199/
https://ncbi.nlm.nih.gov/pubmed/32499373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012983
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