Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment

Accumulating evidence suggests that the lesions of Parkinson’s disease (PD) expand due to transneuronal spreading of fibrils composed of misfolded alpha-synuclein (a-syn), over the course of 5–10 years. However, the precise mechanisms and the processes underlying the spread of these fibril seeds hav...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Okuzumi, Ayami, Kurosawa, Masaru, Hatano, Taku, Takanashi, Masashi, Nojiri, Shuuko, Fukuhara, Takeshi, Yamanaka, Tomoyuki, Miyazaki, Haruko, Yoshinaga, Saki, Furukawa, Yoshiaki, Shimogori, Tomomi, Hattori, Nobutaka, Nukina, Nobuyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145187/
https://ncbi.nlm.nih.gov/pubmed/30231908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0587-0
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