Propeptide glycosylation and galectin‐3 binding decrease proteolytic activation of human proMMP‐9/progelatinase B

Matrix metalloproteinases (MMPs) are secreted as proenzymes, containing propeptides that interact with the catalytic zinc, thereby controlling MMP activation. The MMP‐9 propeptide is unique in the MMP family because of its post‐translational modification with an N‐linked oligosaccharide. ProMMP‐9 ac...

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Publicado en:FEBS J
Main Authors: Boon, Lise, Ugarte‐Berzal, Estefania, Martens, Erik, Vandooren, Jennifer, Rybakin, Vasily, Colau, Didier, Gordon‐Alonso, Monica, van der Bruggen, Pierre, Stöcker, Walter, Becker‐Pauly, Christoph, Witters, Peter, Morava, Eva, Jaeken, Jaak, Proost, Paul, Opdenakker, Ghislain
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7379967/
https://ncbi.nlm.nih.gov/pubmed/30422384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14698
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