Propeptide glycosylation and galectin‐3 binding decrease proteolytic activation of human proMMP‐9/progelatinase B

Matrix metalloproteinases (MMPs) are secreted as proenzymes, containing propeptides that interact with the catalytic zinc, thereby controlling MMP activation. The MMP‐9 propeptide is unique in the MMP family because of its post‐translational modification with an N‐linked oligosaccharide. ProMMP‐9 ac...

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Detalhes bibliográficos
Publicado no:FEBS J
Main Authors: Boon, Lise, Ugarte‐Berzal, Estefania, Martens, Erik, Vandooren, Jennifer, Rybakin, Vasily, Colau, Didier, Gordon‐Alonso, Monica, van der Bruggen, Pierre, Stöcker, Walter, Becker‐Pauly, Christoph, Witters, Peter, Morava, Eva, Jaeken, Jaak, Proost, Paul, Opdenakker, Ghislain
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7379967/
https://ncbi.nlm.nih.gov/pubmed/30422384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14698
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