Exploitation of Langerhans cells for in vivo DNA vaccine delivery into the lymph nodes

There is no clinically available cancer immunotherapy that exploits Langerhans cells (LCs), the epidermal precursors of dendritic cells that are the natural agent of antigen delivery. We developed a DNA formulation with a polymer and obtained synthetic ‘pathogen-like’ nanoparticles that preferential...

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Publicat a:Gene Ther
Autors principals: Tőke, Enikő R., Lőrincz, Orsolya, Csiszovszki, Zsolt, Somogyi, Eszter, Felföldi, Gabriella, Molnár, Levente, Szipőcs, Róbert, Kolonics, Attila, Malissen, Bernard, Lori, Franco, Trocio, Jeffrey, Bakare, Nyasha, Horkay, Ferenc, Romani, Nikolaus, Tripp, Christoph H., Stoitzner, Patrizia, Lisziewicz, Julianna
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7374498/
https://ncbi.nlm.nih.gov/pubmed/24694539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.29
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