Exploitation of Langerhans cells for in vivo DNA vaccine delivery into the lymph nodes

There is no clinically available cancer immunotherapy that exploits Langerhans cells (LCs), the epidermal precursors of dendritic cells that are the natural agent of antigen delivery. We developed a DNA formulation with a polymer and obtained synthetic ‘pathogen-like’ nanoparticles that preferential...

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Détails bibliographiques
Publié dans:Gene Ther
Auteurs principaux: Tőke, Enikő R., Lőrincz, Orsolya, Csiszovszki, Zsolt, Somogyi, Eszter, Felföldi, Gabriella, Molnár, Levente, Szipőcs, Róbert, Kolonics, Attila, Malissen, Bernard, Lori, Franco, Trocio, Jeffrey, Bakare, Nyasha, Horkay, Ferenc, Romani, Nikolaus, Tripp, Christoph H., Stoitzner, Patrizia, Lisziewicz, Julianna
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7374498/
https://ncbi.nlm.nih.gov/pubmed/24694539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.29
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