Exploitation of Langerhans cells for in vivo DNA vaccine delivery into the lymph nodes

There is no clinically available cancer immunotherapy that exploits Langerhans cells (LCs), the epidermal precursors of dendritic cells that are the natural agent of antigen delivery. We developed a DNA formulation with a polymer and obtained synthetic ‘pathogen-like’ nanoparticles that preferential...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Tőke, Enikő R., Lőrincz, Orsolya, Csiszovszki, Zsolt, Somogyi, Eszter, Felföldi, Gabriella, Molnár, Levente, Szipőcs, Róbert, Kolonics, Attila, Malissen, Bernard, Lori, Franco, Trocio, Jeffrey, Bakare, Nyasha, Horkay, Ferenc, Romani, Nikolaus, Tripp, Christoph H., Stoitzner, Patrizia, Lisziewicz, Julianna
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7374498/
https://ncbi.nlm.nih.gov/pubmed/24694539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.29
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