Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug therapy

BACKGROUND: Kidney transplant recipients (KTRs) with “operational tolerance” (OT) maintain a functioning graft without immunosuppressive (IS) drugs, thus avoiding treatment complications. Nevertheless, IS drugs can influence gene-expression signatures aiming to identify OT among treated KTRs. METHOD...

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Bibliographic Details
Published in:EBioMedicine
Main Authors: Christakoudi, Sofia, Runglall, Manohursingh, Mobillo, Paula, Rebollo-Mesa, Irene, Tsui, Tjir-Li, Nova-Lamperti, Estefania, Taube, Catharine, Norris, Sonia, Kamra, Yogesh, Hilton, Rachel, Augustine, Titus, Bhandari, Sunil, Baker, Richard, Berglund, David, Carr, Sue, Game, David, Griffin, Sian, Kalra, Philip A., Lewis, Robert, Mark, Patrick B., Marks, Stephen D., MacPhee, Iain, McKane, William, Mohaupt, Markus G., Paz-Artal, Estela, Kon, Sui Phin, Serón, Daniel, Sinha, Manish D., Tucker, Beatriz, Viklický, Ondrej, Stahl, Daniel, Lechler, Robert I., Lord, Graham M., Hernandez-Fuentes, Maria P.
Format: Artigo
Language:Inglês
Published: Elsevier 2020
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Research paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7374249/
https://ncbi.nlm.nih.gov/pubmed/32707447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102899
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