Biomarkers of tolerance: searching for the hidden phenotype

por Perucha, Esperanza, Rebollo-Mesa, Irene, Sagoo, Pervinder, Hernandez-Fuentes, Maria P
Publicado 2011

A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy

por Canavan, James B., Afzali, Behdad, Scottà, Cristiano, Fazekasova, Henrieta, Edozie, Francis C., Macdonald, Thomas T., Hernandez-Fuentes, Maria P., Lombardi, Giovanna, Lord, Graham M.
Publicado 2012

IL-10-produced by human transitional B-cells down-regulates CD86 expression on B-cells leading to inhibition of CD4(+)T-cell responses

por Nova-Lamperti, Estefania, Fanelli, Giorgia, Becker, Pablo D., Chana, Prabhjoat, Elgueta, Raul, Dodd, Philippa C., Lord, Graham M., Lombardi, Giovanna, Hernandez-Fuentes, Maria P.
Publicado en Sci Rep (2016)

Increased CD40 ligation and reduced BCR signalling leads to higher IL-10 production in B-cells from tolerant kidney transplant patients

por Nova-Lamperti, Estefania, Chana, Prabhjoat, Mobillo, Paula, Runglall, Manohursingh, Kamra, Yogesh, McGregor, Reuben, Lord, Graham M., Lechler, Robert I., Lombardi, Giovanna, Hernandez-Fuentes, Maria P.
Publicado en Transplantation (2017)

A common gene signature across multiple studies relate biomarkers and functional regulation in tolerance to renal allograft

por Baron, Daniel, Ramstein, Gérard, Chesneau, Mélanie, Echasseriau, Yann, Pallier, Annaick, Paul, Chloé, Degauque, Nicolas, Hernandez-Fuentes, Maria P, Sanchez-Fueyo, Alberto, Newell, Kenneth A, Giral, Magali, Soulillou, Jean-Paul, Houlgatte, Rémi, Brouard, Sophie
Publicado en Kidney Int (2015)

Graft dysfunction in chronic antibody-mediated rejection correlates with B-cell–dependent indirect antidonor alloresponses and autocrine regulation of interferon-γ production by Th...

por Shiu, Kin Yee, McLaughlin, Laura, Rebollo-Mesa, Irene, Zhao, Jingyue, Burton, Hannah, Douthwaite, Harriet, Wilkinson, Hannah, Semik, Vikki, Dodd, Philippa C., Brookes, Paul, Lechler, Robert I., Hernandez-Fuentes, Maria P., Kemper, Claudia, Dorling, Anthony
Publicado en Kidney Int (2017)

Reduced TCR-signalling contributes to impaired Th17 responses in tolerant kidney transplant recipients

por Nova-Lamperti, Estefania, Romano, Marco, Christakoudi, Sofia, Runglall, Manohursingh, McGregor, Reuben, Mobillo, Paula, Kamra, Yogesh, Tsui, Tjir-Li, Norris, Sonia, John, Susan, Boardman, Dominic A., Lechler, Robert I., Lombardi, Giovanna, Hernandez-Fuentes, Maria P.
Publicado en Transplantation (2018)

Identification of a B cell signature associated with renal transplant tolerance in humans

por Newell, Kenneth A., Asare, Adam, Kirk, Allan D., Gisler, Trang D., Bourcier, Kasia, Suthanthiran, Manikkam, Burlingham, William J., Marks, William H., Sanz, Ignacio, Lechler, Robert I., Hernandez-Fuentes, Maria P., Turka, Laurence A., Seyfert-Margolis, Vicki L.
Publicado 2010

Monitoring T-Cell Responses in Translational Studies: Optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-Specific Responses

por Ten Brinke, Anja, Marek-Trzonkowska, Natalia, Mansilla, Maria J., Turksma, Annelies W., Piekarska, Karolina, Iwaszkiewicz-Grześ, Dorota, Passerini, Laura, Locafaro, Grazia, Puñet-Ortiz, Joan, van Ham, S. Marieke, Hernandez-Fuentes, Maria P., Martínez-Cáceres, Eva M., Gregori, Silvia
Publicado en Front Immunol (2017)

Corrigendum: Monitoring T-Cell Responses in Translational Studies: Optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-Specific Responses

por Ten Brinke, Anja, Marek-Trzonkowska, Natalia, Mansilla, Maria J., Turksma, Annelies W., Piekarska, Karolina, Iwaszkiewicz-Grześ, Dorota, Passerini, Laura, Locafaro, Grazia, Puñet-Ortiz, Joan, van Ham, S. Marieke, Hernandez-Fuentes, Maria P., Martínez-Cáceres, Eva M., Gregori, Silvia
Publicado en Front Immunol (2018)

Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and lo...

por Christakoudi, Sofia, Runglall, Manohursingh, Mobillo, Paula, Tsui, Tjir-Li, Duff, Claire, Domingo-Vila, Clara, Kamra, Yogesh, Delaney, Florence, Montero, Rosa, Spiridou, Anastasia, Kassimatis, Theodoros, Phin-Kon, Sui, Tucker, Beatriz, Farmer, Christopher, Strom, Terry B., Lord, Graham M., Rebollo-Mesa, Irene, Stahl, Daniel, Sacks, Steven, Hernandez-Fuentes, Maria P., Chowdhury, Paramit
Publicado en EBioMedicine (2019)

Developing in vitro expanded CD45RA(+) regulatory T cells as an adoptive cell therapy for Crohn's disease

por Canavan, James B, Scottà, Cristiano, Vossenkämper, Anna, Goldberg, Rimma, Elder, Matthew J, Shoval, Irit, Marks, Ellen, Stolarczyk, Emilie, Lo, Jonathan W, Powell, Nick, Fazekasova, Henrieta, Irving, Peter M, Sanderson, Jeremy D, Howard, Jane K, Yagel, Simcha, Afzali, Behdad, MacDonald, Thomas T, Hernandez-Fuentes, Maria P, Shpigel, Nahum Y, Lombardi, Giovanna, Lord, Graham M
Publicado en Gut (2016)

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans

por Sagoo, Pervinder, Perucha, Esperanza, Sawitzki, Birgit, Tomiuk, Stefan, Stephens, David A., Miqueu, Patrick, Chapman, Stephanie, Craciun, Ligia, Sergeant, Ruhena, Brouard, Sophie, Rovis, Flavia, Jimenez, Elvira, Ballow, Amany, Giral, Magali, Rebollo-Mesa, Irene, Le Moine, Alain, Braudeau, Cecile, Hilton, Rachel, Gerstmayer, Bernhard, Bourcier, Katarzyna, Sharif, Adnan, Krajewska, Magdalena, Lord, Graham M., Roberts, Ian, Goldman, Michel, Wood, Kathryn J., Newell, Kenneth, Seyfert-Margolis, Vicki, Warrens, Anthony N., Janssen, Uwe, Volk, Hans-Dieter, Soulillou, Jean-Paul, Hernandez-Fuentes, Maria P., Lechler, Robert I.
Publicado 2010

Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug...

por Christakoudi, Sofia, Runglall, Manohursingh, Mobillo, Paula, Rebollo-Mesa, Irene, Tsui, Tjir-Li, Nova-Lamperti, Estefania, Taube, Catharine, Norris, Sonia, Kamra, Yogesh, Hilton, Rachel, Augustine, Titus, Bhandari, Sunil, Baker, Richard, Berglund, David, Carr, Sue, Game, David, Griffin, Sian, Kalra, Philip A., Lewis, Robert, Mark, Patrick B., Marks, Stephen D., MacPhee, Iain, McKane, William, Mohaupt, Markus G., Paz-Artal, Estela, Kon, Sui Phin, Serón, Daniel, Sinha, Manish D., Tucker, Beatriz, Viklický, Ondrej, Stahl, Daniel, Lechler, Robert I., Lord, Graham M., Hernandez-Fuentes, Maria P.
Publicado en EBioMedicine (2020)

Long‐ and short‐term outcomes in renal allografts with deceased donors: A large recipient and donor genome‐wide association study

por Hernandez‐Fuentes, Maria P., Franklin, Christopher, Rebollo‐Mesa, Irene, Mollon, Jennifer, Delaney, Florence, Perucha, Esperanza, Stapleton, Caragh, Borrows, Richard, Byrne, Catherine, Cavalleri, Gianpiero, Clarke, Brendan, Clatworthy, Menna, Feehally, John, Fuggle, Susan, Gagliano, Sarah A., Griffin, Sian, Hammad, Abdul, Higgins, Robert, Jardine, Alan, Keogan, Mary, Leach, Timothy, MacPhee, Iain, Mark, Patrick B., Marsh, James, Maxwell, Peter, McKane, William, McLean, Adam, Newstead, Charles, Augustine, Titus, Phelan, Paul, Powis, Steve, Rowe, Peter, Sheerin, Neil, Solomon, Ellen, Stephens, Henry, Thuraisingham, Raj, Trembath, Richard, Topham, Peter, Vaughan, Robert, Sacks, Steven H., Conlon, Peter, Opelz, Gerhard, Soranzo, Nicole, Weale, Michael E., Lord, Graham M.
Publicado en Am J Transplant (2018)

The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population.

por Stapleton, Caragh P., Heinzel, Andreas, Guan, Weihua, van der Most, Peter J., van Setten, Jessica, Lord, Graham M., Keating, Brendan J., Israni, Ajay K., de Borst, Martin H., Bakker, Stephan J.L., Snieder, Harold, Weale, Michael E., Delaney, Florence, Hernandez‐Fuentes, Maria P., Reindl-Schwaighofer, Roman, Oberbauer, Rainer, Jacobson, Pamala A., Mark, Patrick B., Chapman, Fiona A., Phelan, Paul J., Kennedy, Claire, Sexton, Donal, Murray, Susan, Jardine, Alan, Traynor, Jamie P., McKnight, Amy Jayne, Maxwell, Alexander P., Smyth, Laura J., Oetting, William S., Matas, Arthur J., Mannon, Roslyn B., Schladt, David P., Iklé, David N., Cavalleri, Gianpiero L., Conlon, Peter J.
Publicado en Am J Transplant (2019)

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

por Sawitzki, Birgit, Harden, Paul N, Reinke, Petra, Moreau, Aurélie, Hutchinson, James A, Game, David S, Tang, Qizhi, Guinan, Eva C, Battaglia, Manuela, Burlingham, William J, Roberts, Ian S D, Streitz, Mathias, Josien, Régis, Böger, Carsten A, Scottà, Cristiano, Markmann, James F, Hester, Joanna L, Juerchott, Karsten, Braudeau, Cecile, James, Ben, Contreras-Ruiz, Laura, van der Net, Jeroen B, Bergler, Tobias, Caldara, Rossana, Petchey, William, Edinger, Matthias, Dupas, Nathalie, Kapinsky, Michael, Mutzbauer, Ingrid, Otto, Natalie M, Öllinger, Robert, Hernandez-Fuentes, Maria P, Issa, Fadi, Ahrens, Norbert, Meyenberg, Christoph, Karitzky, Sandra, Kunzendorf, Ulrich, Knechtle, Stuart J, Grinyó, Josep, Morris, Peter J, Brent, Leslie, Bushell, Andrew, Turka, Laurence A, Bluestone, Jeffrey A, Lechler, Robert I, Schlitt, Hans J, Cuturi, Maria C, Schlickeiser, Stephan, Friend, Peter J, Miloud, Tewfik, Scheffold, Alexander, Secchi, Antonio, Crisalli, Kerry, Kang, Sang-Mo, Hilton, Rachel, Banas, Bernhard, Blancho, Gilles, Volk, Hans-Dieter, Lombardi, Giovanna, Wood, Kathryn J, Geissler, Edward K
Publicado en Lancet (2020)