Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples

BACKGROUND: Acute T-cell mediated rejection (TCMR) is usually indicated by alteration in serum-creatinine measurements when considerable transplant damage has already occurred. There is, therefore, a need for non-invasive early detection of immune signals that would precede the onset of rejection, p...

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Publicado en:EBioMedicine
Autores principales: Christakoudi, Sofia, Runglall, Manohursingh, Mobillo, Paula, Tsui, Tjir-Li, Duff, Claire, Domingo-Vila, Clara, Kamra, Yogesh, Delaney, Florence, Montero, Rosa, Spiridou, Anastasia, Kassimatis, Theodoros, Phin-Kon, Sui, Tucker, Beatriz, Farmer, Christopher, Strom, Terry B., Lord, Graham M., Rebollo-Mesa, Irene, Stahl, Daniel, Sacks, Steven, Hernandez-Fuentes, Maria P., Chowdhury, Paramit
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441872/
https://ncbi.nlm.nih.gov/pubmed/30833191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.01.060
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