Increased CD40 ligation and reduced BCR signalling leads to higher IL-10 production in B-cells from tolerant kidney transplant patients

BACKGROUND: An increased percentage of peripheral transitional B-cells producing IL-10 has been observed in patients tolerant to kidney allografts. In healthy volunteers, the balance between the CD40 and B-cell receptor (BCR) signalling modulated IL-10 production by B-cells, with stimulation via the...

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Publicado no:Transplantation
Main Authors: Nova-Lamperti, Estefania, Chana, Prabhjoat, Mobillo, Paula, Runglall, Manohursingh, Kamra, Yogesh, McGregor, Reuben, Lord, Graham M., Lechler, Robert I., Lombardi, Giovanna, Hernandez-Fuentes, Maria P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5178883/
https://ncbi.nlm.nih.gov/pubmed/27472092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000001341
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