Reduced TCR-signalling contributes to impaired Th17 responses in tolerant kidney transplant recipients

BACKGROUND: The development of spontaneous kidney transplant tolerance has been associated with numerous B cell-related immune alterations. We have previously shown that tolerant recipients exhibit reduced B cell receptor (BCR) signalling and higher IL-10 production than healthy volunteers. However,...

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Publicado en:Transplantation
Autores principales: Nova-Lamperti, Estefania, Romano, Marco, Christakoudi, Sofia, Runglall, Manohursingh, McGregor, Reuben, Mobillo, Paula, Kamra, Yogesh, Tsui, Tjir-Li, Norris, Sonia, John, Susan, Boardman, Dominic A., Lechler, Robert I., Lombardi, Giovanna, Hernandez-Fuentes, Maria P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737900/
https://ncbi.nlm.nih.gov/pubmed/28902773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000001920
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