Developing in vitro expanded CD45RA(+) regulatory T cells as an adoptive cell therapy for Crohn's disease

BACKGROUND AND AIM: Thymus-derived regulatory T cells (T(regs)) mediate dominant peripheral tolerance and treat experimental colitis. T(regs) can be expanded from patient blood and were safely used in recent phase 1 studies in graft versus host disease and type 1 diabetes. T(reg) cell therapy is als...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Canavan, James B, Scottà, Cristiano, Vossenkämper, Anna, Goldberg, Rimma, Elder, Matthew J, Shoval, Irit, Marks, Ellen, Stolarczyk, Emilie, Lo, Jonathan W, Powell, Nick, Fazekasova, Henrieta, Irving, Peter M, Sanderson, Jeremy D, Howard, Jane K, Yagel, Simcha, Afzali, Behdad, MacDonald, Thomas T, Hernandez-Fuentes, Maria P, Shpigel, Nahum Y, Lombardi, Giovanna, Lord, Graham M
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Inflammatory Bowel Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819603/
https://ncbi.nlm.nih.gov/pubmed/25715355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-306919
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