Developing in vitro expanded CD45RA(+) regulatory T cells as an adoptive cell therapy for Crohn's disease

BACKGROUND AND AIM: Thymus-derived regulatory T cells (T(regs)) mediate dominant peripheral tolerance and treat experimental colitis. T(regs) can be expanded from patient blood and were safely used in recent phase 1 studies in graft versus host disease and type 1 diabetes. T(reg) cell therapy is als...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Gut
Prif Awduron: Canavan, James B, Scottà, Cristiano, Vossenkämper, Anna, Goldberg, Rimma, Elder, Matthew J, Shoval, Irit, Marks, Ellen, Stolarczyk, Emilie, Lo, Jonathan W, Powell, Nick, Fazekasova, Henrieta, Irving, Peter M, Sanderson, Jeremy D, Howard, Jane K, Yagel, Simcha, Afzali, Behdad, MacDonald, Thomas T, Hernandez-Fuentes, Maria P, Shpigel, Nahum Y, Lombardi, Giovanna, Lord, Graham M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMJ Publishing Group 2016
Pynciau:
Inflammatory Bowel Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819603/
https://ncbi.nlm.nih.gov/pubmed/25715355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-306919
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