Developing in vitro expanded CD45RA(+) regulatory T cells as an adoptive cell therapy for Crohn's disease

BACKGROUND AND AIM: Thymus-derived regulatory T cells (T(regs)) mediate dominant peripheral tolerance and treat experimental colitis. T(regs) can be expanded from patient blood and were safely used in recent phase 1 studies in graft versus host disease and type 1 diabetes. T(reg) cell therapy is als...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Gut
Autores principales: Canavan, James B, Scottà, Cristiano, Vossenkämper, Anna, Goldberg, Rimma, Elder, Matthew J, Shoval, Irit, Marks, Ellen, Stolarczyk, Emilie, Lo, Jonathan W, Powell, Nick, Fazekasova, Henrieta, Irving, Peter M, Sanderson, Jeremy D, Howard, Jane K, Yagel, Simcha, Afzali, Behdad, MacDonald, Thomas T, Hernandez-Fuentes, Maria P, Shpigel, Nahum Y, Lombardi, Giovanna, Lord, Graham M
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2016
Materias:
Inflammatory Bowel Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819603/
https://ncbi.nlm.nih.gov/pubmed/25715355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-306919
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares