Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptosis, all depend on iron metabolism. Ferrous iron accumulates over adult lifetime in Caenorhabditis elegans. Here, we show that glutathione depletion is coupled to ferrous iro...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Jenkins, Nicole L, James, Simon A, Salim, Agus, Sumardy, Fransisca, Speed, Terence P, Conrad, Marcus, Richardson, Des R, Bush, Ashley I, McColl, Gawain
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2020
Gaiak:
Biochemistry and Chemical Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373428/
https://ncbi.nlm.nih.gov/pubmed/32690135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56580
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