Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptosis, all depend on iron metabolism. Ferrous iron accumulates over adult lifetime in Caenorhabditis elegans. Here, we show that glutathione depletion is coupled to ferrous iro...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Jenkins, Nicole L, James, Simon A, Salim, Agus, Sumardy, Fransisca, Speed, Terence P, Conrad, Marcus, Richardson, Des R, Bush, Ashley I, McColl, Gawain
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373428/
https://ncbi.nlm.nih.gov/pubmed/32690135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56580
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