Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptosis, all depend on iron metabolism. Ferrous iron accumulates over adult lifetime in Caenorhabditis elegans. Here, we show that glutathione depletion is coupled to ferrous iro...

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Vydáno v:eLife
Hlavní autoři: Jenkins, Nicole L, James, Simon A, Salim, Agus, Sumardy, Fransisca, Speed, Terence P, Conrad, Marcus, Richardson, Des R, Bush, Ashley I, McColl, Gawain
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373428/
https://ncbi.nlm.nih.gov/pubmed/32690135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56580
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