Inhibition of miR-21 regulates mutant KRAS effector pathways and intercepts pancreatic ductal adenocarcinoma development

Almost all pancreatic ductal adenocarcinomas (PDA) develop following KRAS activation which triggers epithelial transformation and recruitment of desmoplastic stroma through additional transcriptional and epigenetic regulation, but only a few of these regulatory mechanisms have been described. We pro...

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Foilsithe in:Cancer Prev Res (Phila)
Main Authors: Chu, Nina J., Anders, Robert A., Fertig, Elana J., Cao, Minwei, Hopkins, Alexander C., Keenan, Bridget P., Popovic, Aleksandra, Armstrong, Todd D., Jaffee, Elizabeth M., Zimmerman, Jacquelyn W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372516/
https://ncbi.nlm.nih.gov/pubmed/32409593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-20-0053
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