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KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in KRAS and frequent deregulation of crucial embryonic signalling pathways, including the Hedgehog (Hh) and Wnt–β-catenin cascades. The creation of mouse models that closely resemble the human disease has provided a...

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Detaylı Bibliyografya
Asıl Yazarlar: Morris, John P., Wang, Sam C., Hebrok, Matthias
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085546/
https://ncbi.nlm.nih.gov/pubmed/20814421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2899
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