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β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
Cellular plasticity in adult organs is involved in both regeneration and carcinogenesis. WT mouse acinar cells rapidly regenerate following injury that mimics acute pancreatitis, a process characterized by transient reactivation of pathways involved in embryonic pancreatic development. In contrast,...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Clinical Investigation
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2810083/ https://ncbi.nlm.nih.gov/pubmed/20071774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40045 |
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