Načítá se...

Integrative x-ray structure and molecular modeling for the rationalization of procaspase-8 inhibitor potency and selectivity

Caspases are a critical class of proteases involved in regulating programmed cell death and other biological processes. Selective inhibitors of individual caspases, however, are lacking, due in large part to the high structural similarity found in the active sites of these enzymes. We recently disco...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:ACS Chem Biol
Hlavní autoři: Xu, Janice H., Eberhardt, Jerome, Hill-Payne, Brianna, González-Páez, Gonzalo E., Castellón, José Omar, Cravatt, Benjamin F., Forli, Stefano, Wolan, Dennis W., Backus, Keriann M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7370820/
https://ncbi.nlm.nih.gov/pubmed/31927936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00019
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!