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Fibrils Colocalize Caspase-3 with Procaspase-3 to Foster Maturation
Most proteases are expressed as inactive precursors, or zymogens, that become activated by limited proteolysis. We previously identified a small molecule, termed 1541, that dramatically promotes the maturation of the zymogen, procaspase-3, to its mature form, caspase-3. Surprisingly, compound 1541 s...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3460474/ https://ncbi.nlm.nih.gov/pubmed/22872644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.386128 |
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