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Substrate and Inhibitor-induced Dimerization and Cooperativity in Caspase-1 but Not Caspase-3

Caspases are intracellular cysteine-class proteases with aspartate specificity that is critical for driving processes as diverse as the innate immune response and apoptosis, exemplified by caspase-1 and caspase-3, respectively. Interestingly, caspase-1 cleaves far fewer cellular substrates than casp...

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Detalhes bibliográficos
Main Authors: Datta, Debajyoti, McClendon, Christopher L., Jacobson, Matthew P., Wells, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617296/
https://ncbi.nlm.nih.gov/pubmed/23386603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.426460
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