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An Allosteric Circuit in Caspase-1
Structural studies of caspase-1 reveal that the dimeric thiol protease can exist in two states: in an on-state, when the active site is occupied, or in an off-state, when the active site is empty or when the enzyme is bound by a synthetic allosteric ligand at the dimer interface ∼15 Å from the activ...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2626611/ https://ncbi.nlm.nih.gov/pubmed/18590738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.06.040 |
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