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Dissecting an Allosteric Switch in Caspase-7 Using Chemical and Mutational Probes
Apoptotic caspases, such as caspase-7, are stored as inactive protease zymogens, and when activated, lead to a fate-determining switch to induce cell death. We previously discovered small molecule thiol-containing inhibitors that when tethered revealed an allosteric site and trapped a conformation s...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2758006/ https://ncbi.nlm.nih.gov/pubmed/19581639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.001826 |
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